MODULATING AND STIMULATING THE IMMUNE SYSTEM THERAPY IN PEOPLE WITH HIV/AIDS - ADVANTAGES AND POSSIBILITIES - REVIEW OF THE LITERATURE WITH SHARING OF OWN EXPERIENCE

Authors

  • L. Pekova Department of Hygiene, Epidemiology, Microbiology, Parasitology and Infectious Diseases, Medical Faculty, Trakia University, Stara Zagora, Bulgaria, Clinic of Infectious Diseases, University Hospital for Active Treatment “Prof. Stoyan Kirkovich”-AD, Stara Zagora, Bulgaria Author
  • S. Angelova Department of Hygiene, Epidemiology, Microbiology, Parasitology and Infectious Diseases, Medical Faculty, Trakia University, Stara Zagora, Bulgaria Translator
  • P. Parusheva Department of Hygiene, Epidemiology, Microbiology, Parasitology and Infectious Diseases, Medical Faculty, Trakia University, Stara Zagora, Bulgaria, Clinic of Infectious Diseases, University Hospital for Active Treatment “Prof. Stoyan Kirkovich”-AD, Stara Zagora, Bulgaria Author
  • B. Bureva Department of Hygiene, Epidemiology, Microbiology, Parasitology and Infectious Diseases, Medical Faculty, Trakia University, Stara Zagora, Bulgaria, Clinic of Infectious Diseases, University Hospital for Active Treatment “Prof. Stoyan Kirkovich”-AD, Stara Zagora, Bulgaria Author
  • M. Mitev Department of Medical Physics, Biophysics, X-ray and Radiology Medical Faculty, Trakia University, Stara Zagora, Bulgaria Author

DOI:

https://doi.org/10.15547/tjs.2024.03.011

Keywords:

immunomodulatory drugs, HIV/AIDS, Pn. jirovecii pneumonia

Abstract

The immune system in people living with HIV can range from normal to severely dysfunctional, depending on the timing of ART initiation and adherence. The use of immunostimulating and immunomodulating drugs in HIV/AIDS still hides many unknowns. Various types of immunotherapy, including monoclonal antibodies, interferon, cytokines, immunomodulatory drugs, allogeneic hematopoietic stem cell transplantation, and most importantly ART adherence, have shown efficacy in HIV-associated opportunistic infections and neoplasms. The beneficial effect of immunotherapy in autoimmune, inflammatory and oncological diseases in the course of HIV/AIDS is based on reducing the pathological damage of the immune system and modifying the disease processes by interfering with cellular metabolism and nucleic acid synthesis, as well as the production of antagonist molecules of inflammation. While most known immunomodulators reduce pathological disorders of the immune system, newer "checkpoint inhibitors" have been developed to improve immune surveillance in oncological diseases. Some cancer immunotherapies can affect HIV latency and HIV-specific immunity. Knowing the benefits of immunotherapy in people with HIV/AIDS and opportunistic diseases will improve their clinical care, providing a unique opportunity to gain insight into the mechanisms of HIV eradication. We present two cases of AIDS and Pneumocystis jirovecii pneumonia where we administered immunomodulators concurrently with ART and specific etiologic therapy. One patient died.

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Published

2024-09-24

How to Cite

MODULATING AND STIMULATING THE IMMUNE SYSTEM THERAPY IN PEOPLE WITH HIV/AIDS - ADVANTAGES AND POSSIBILITIES - REVIEW OF THE LITERATURE WITH SHARING OF OWN EXPERIENCE. (2024). TRAKIA JOURNAL OF SCIENCES, 22(3), 9. https://doi.org/10.15547/tjs.2024.03.011