MAJOR DEPRESSIVE DISORDER, TYPE 2 DIABETES MELLITUS AND INFLAMMATION
DOI:
https://doi.org/10.15547/tjs.2024.04.008Keywords:
Inflammation, depression, diabetesAbstract
Inflammation may play a key role in the pathogenesis of both depression and type 2 diabetes. However, elevated levels of circulating IL-6 are an independent predictor of type 2 diabetes and are thought to occur with the development of insulin resistance and β-cell dysfunction. There is no evidence linking IL-6 to β-cell dysfunction and eventual β-cell apoptosis. Elevated levels of IL-6 are always associated with increased hypothalamic-pituitary-adrenal (HPA) activity in depression. This increases cortisol, which then triggers TDO and reduces the availability of tryptophan for the production of melatonin, NAS and serotonin. Therefore, IL-6 contributes to the regulation of important biological pathways that underlie stress and the subsequent depression that results from stress.
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