WHICH CLINICAL PARAMETERS HAVE IMPACT ON OUTCOME IN THE EARLY PHASE OF COMPLICATED INTRA-ABDOMINAL INFECTION? – A PROSPECTIVE STUDY

Authors

  • E. Dimitrov Clinic of Surgical Diseases, University Hospital “Prof. Dr. Stoyan Kirkovich” Stara Zagora, Bulgaria, Department of Surgical Diseases and Anesthesiology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria Author
  • G. Minkov Clinic of Surgical Diseases, University Hospital “Prof. Dr. Stoyan Kirkovich” Stara Zagora, Bulgaria, Department of Surgical Diseases and Anesthesiology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria Author
  • E. Enchev Clinic of Surgical Diseases, University Hospital “Prof. Dr. Stoyan Kirkovich” Stara Zagora, Bulgaria, Department of Surgical Diseases and Anesthesiology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria Author
  • Y. Yovtchev Clinic of Surgical Diseases, University Hospital “Prof. Dr. Stoyan Kirkovich” Stara Zagora, Bulgaria, Department of Surgical Diseases and Anesthesiology, Faculty of Medicine, Trakia University, Stara Zagora, Bulgaria Author

DOI:

https://doi.org/10.15547/tjs.2024.01.008

Keywords:

clinical parameters, SIRS, intra-abdominal infections, cIAIs , outcome, prognosis

Abstract

Purpose: There is still no comprehensive analysis with Bulgarian patients investigating the association between perioperative clinical parameters and final outcome in the early phase of complicated intra-abdominal infection.

Methods: This single-center prospective study was conducted in the Clinic of Surgical Diseases at the University Hospital Stara-Zagora for the period November 2018 - August 2021. Before surgery and on the 3rd postoperative day (POD) we measured axillary temperature (t), systolic blood pressure (SBP), mean arterial pressure (MAP), respiratory rate (RR), heart rate (HR), mental status and systemic inflammatory response syndrome (SIRS) in 62 patients with complicated intra-abdominal infections (cIAIs).

Results: Of the 62 patients, nine died (14.5%). Preoperatively, only MAP successfully discriminated survivors from non-survivors (p = 0.027), which was confirmed by the ROC Curve analysis (AUROC = 0.731). Postoperatively, almost all of the clinical parameters except axillary temperature (AUROC = 0.573) showed prognostic ability – SBP (AUROC = 0.779) and MAP (AUROC = 0.864) for prediction of favorable outcome, HR (AUROC = 0.916) and RR (AUROC = 0.935) for prediction of lethal outcome.

Conclusion: All investigated clinical parameters, except for axillary temperature, demonstrated the ability to predict the final outcome on the 3rd POD in patients with cIAIs.

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Published

2024-06-05

Issue

Vol. 22 No. 1 (2024): Series Biomedical Sciences

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Original Contributions

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WHICH CLINICAL PARAMETERS HAVE IMPACT ON OUTCOME IN THE EARLY PHASE OF COMPLICATED INTRA-ABDOMINAL INFECTION? – A PROSPECTIVE STUDY. (2024). TRAKIA JOURNAL OF SCIENCES, 22(1), 9. https://doi.org/10.15547/tjs.2024.01.008