RISK STRATIFICATION IN CIRRHOTIC PATIENTS UNDERGOING NONHEPATIC SURGERY – LITERATURE REVIEW

Authors

  • E. Merashka Department of Surgical Diseases, Faculty of Medicine, Medical University in Pleven, Bulgaria Author

DOI:

https://doi.org/10.15547/tjs.2025.01.010

Keywords:

Child – Pugh – Turcotte, liver dysfunction, MELD, cirrhosis

Abstract

Liver cirrhosis is a socially significant chronic disease affecting people of working age that leads to severe, life-threatening complications in the absence of adequate treatment. In the course of the disease, numerous pathophysiological changes develop in the body of the affected patients, leading to permanent reorganization of the functional activity of the cardiovascular, respiratory, excretory systems, as well as deviations in the coagulation and immunological status of patients. The above-listed dysfunctions lead to increased mortality rates and development of complications in the perioperative period in these patients, which makes them unsuitable candidates for surgical treatment.

Risk stratification in this patient population and careful selection of suitable surgical candidates require a detailed assessment of the clinical condition of patients and its optimization in order to reduce the initially increased levels of morbidity and mortality. The existing scoring systems that are used with the highest frequency in clinical practice – Child – Pugh – Turcotte and MELD, show similar levels of predictive value in terms of surgical risk. The latter can be adequately defined when they are used simultaneously and implemented in daily clinical practice in patients undergoing emergency or elective non-hepatic surgery.

References

Bleszynski, M. S.; Bressan, A. K.; Joos, E.; Morad Hameed, S.; Ball, C. G. Acute Care and Emergency General Surgery in Patients with Chronic Liver Disease: How Can We Optimize Perioperative Care? A Review of the Literature. World J Emerg Surg 2018, 13 (1), 32. https://doi.org/10.1186/s13017-018-0194-1.

Millwala, F. Outcomes of Patients with Cirrhosis Undergoing Non-Hepatic Surgery: Risk Assessment and Management. WJG 2007, 13 (30), 4056. https://doi.org/10.3748/wjg.v13.i30.4056.

Mateos, R. M. Pre-Surgical Risk Assessment in Patients with Cirrhosis. 2020, 83.

Gerard V. Aranha, Stephen J. Sontag, Herbert B. Greenlee, Cholecystectomy in cirrhotic patients: A formidable operation, The American Journal of Surgery, Volume 143, Issue 1, 1982,Pages 55-60,ISSN 0002-9610, https://doi.org/10.1016/0002-9610(82)90129-5.

Tinkoff, G.; Rhodes, M.; Diamond, D.; Lucke, J. Cirrhosis in the Trauma Victim Effect on Mortality Rates: Annals of Surgery 1990, 211 (2), 172–177 https://doi.org/10.1097/00000658-199002000-00009.

Newman, K. L.; Johnson, K. M.; Cornia, P. B.; Wu, P.; Itani, K.; Ioannou, G. N. Perioperative Evaluation and Management of Patients With Cirrhosis: Risk Assessment, Surgical Outcomes, and Future Directions. Clinical Gastroenterology and Hepatology 2020, 18 (11), 2398-2414.e3. https://doi.org/10.1016/j.cgh.2019.07.051.

De Goede, B.; Klitsie, P. J.; Lange, J. F.; Metselaar, H. J.; Kazemier, G. Morbidity and Mortality Related to Non-Hepatic Surgery in Patients with Liver Cirrhosis; A Systematic Review. Best Practice & Research Clinical Gastroenterology 2012, 26 (1), 47–59. https://doi.org/10.1016/j.bpg.2012.01.010.

Im, G. Y.; Lubezky, N.; Facciuto, M. E.; Schiano, T. D. Surgery in Patients with Portal Hypertension. Clinics in Liver Disease 2014, 18 (2), 477–505. https://doi.org/10.1016/j.cld.2014.01.006.

Wiklund, R. A. Preoperative Preparation of Patients with Advanced Liver Disease: Critical Care Medicine 2004, 32 (Supplement), S106–S115. https://doi.org/10.1097/01.CCM.0000115624.13479.E6.

Nicoll, A. Surgical Risk in Patients with Cirrhosis. J of Gastro and Hepatol 2012, 27 (10), 1569–1575. https://doi.org/10.1111/j.1440-1746.2012.07205.x.

Abbas, N.; Makker, J.; Abbas, H.; Balar, B. Perioperative Care of Patients With Liver Cirrhosis: A Review. Health�Serv�Insights 2017, 10, 1178632917691270. https://doi.org/10.1177/1178632917691270.

D'Amico G, Pasta L, Morabito A, D'Amico M, Caltagirone M, Malizia G, Tinè F, Giannuoli G, Traina M, Vizzini G, Politi F, Luca A, Virdone R, Licata A, Pagliaro L. Competing risks and prognostic stages of cirrhosis: a 25-year inception cohort study of 494 patients. Aliment Pharmacol Ther. 2014 May;39(10):1180-93. doi: 10.1111/apt.12721. Epub 2014 Mar 24. PMID: 24654740.

Perkins J. The hemodynamics of cirrhosis and the development of hepatorenal syndrome. Liver Transpl. 2006 Jan;12(1):162. PMID: 16498712.

Suman, A.; Carey, W. D. Assessing the Risk of Surgery in Patients with Liver Disease. Cleveland Clinic Journal of Medicine 2006, 73 (4), 398–404. https://doi.org/10.3949/ccjm.73.4.398.

Befeler, A. S. The Safety of Intra-Abdominal Surgery in Patients With Cirrhosis: Model for End-Stage Liver Disease Score Is Superior to Child-Turcotte-Pugh Classification in Predicting Outcome. Arch Surg 2005, 140 (7), 650. https://doi.org/10.1001/archsurg.140.7.650.

Hoteit, M.-A. Model for End-Stage Liver Disease Score versus Child Score in Predicting the Outcome of Surgical Procedures in Patients with Cirrhosis. WJG 2008, 14 (11), 1774. https://doi.org/10.3748/wjg.14.1774.

Douard, R.; Lentschener, C.; Ozier, Y.; Dousset, B. Operative Risks of Digestive Surgery in Cirrhotic Patients. Gastroentérologie Clinique et Biologique 2009, 33 (6–7), 555–564. https://doi.org/10.1016/j.gcb.2009.03.012.

Northup, P. G.; Friedman, L. S.; Kamath, P. S. AGA Clinical Practice Update on Surgical Risk Assessment and Perioperative Management in Cirrhosis: Expert Review. Clinical Gastroenterology and Hepatology 2019, 17 (4), 595–606. https://doi.org/10.1016/j.cgh.2018.09.043.

Teh, S. H.; Nagorney, D. M.; Stevens, S. R.; Offord, K. P.; Therneau, T. M.; Plevak, D. J.; Talwalkar, J. A.; Kim, W. R.; Kamath, P. S. Risk Factors for Mortality After Surgery in Patients With Cirrhosis. Gastroenterology 2007, 132 (4), 1261–1269. https://doi.org/10.1053/j.gastro.2007.01.040.

Hickman, L.; Tanner, L.; Christein, J.; Vickers, S. Non-Hepatic Abdominal Surgery in Patients with Cirrhotic Liver Disease. Journal of Gastrointestinal Surgery 2019, 23 (3), 634–642. https://doi.org/10.1007/s11605-018-3991-7.

Martin Mateos, R.; Maddur, H. A Step Forward to Accurately Predict Mortality in Cirrhotic Patients Undergoing Elective Surgery: The Role of the Hepatic Venous Pressure Gradient. Journal of Hepatology 2019, 71 (5), 862–863. https://doi.org/10.1016/j.jhep.2019.09.001.

El-Ghobary, M.; Salman, A. A.; Shaaban, H. E.-D.; Mostafa, M. S.; Tourky, M. S.; Youssef, O. R.; Omar, M. G. Portal Venous Pressure as a Predictor of Mortality in Child’s A Cirrhotic Patients Undergoing Elective Surgery: A Prospective Study. Open Access Maced J Med Sci 2020, 8 (B), 574–578. https://doi.org/10.3889/oamjms.2020.3373.

Elmahdy, A. M.; Berzigotti, A. Non-Invasive Measurement of Portal Pressure. Curr Hepatology Rep 2019, 18 (1), 20–27. https://doi.org/10.1007/s11901-019-00446-4.

Salman, M. A.; Mansour, D. A.; Balamoun, H. A.; Elbarmelgi, M. Y.; Hadad, K. E. E.; Abo Taleb, M. E.; Salman, A. Portal Venous Pressure as a Predictor of Mortality in Cirrhotic Patients Undergoing Emergency Surgery. Asian Journal of Surgery 2019, 42 (1), 338–342. https://doi.org/10.1016/j.asjsur.2018.09.007.

Nguyen, G. C.; Correia, A. J.; Thuluvath, P. J. The Impact of Cirrhosis and Portal Hypertension on Mortality Following Colorectal Surgery: A Nationwide, Population-Based Study. Diseases of the Colon & Rectum 2009, 52 (8), 1367–1374. https://doi.org/10.1007/DCR.0b013e3181a80dca.

Kim JH, Lee JS, Lee SH, Bae WK, Kim NH, Kim KA, Moon YS. The association between the serum sodium level and the severity of complications in liver cirrhosis. Korean J Intern Med. 2009 Jun;24(2):106-12. doi: 10.3904/kjim.2009.24.2.106. Epub 2009 Jun 8. PMID: 19543488; PMCID: PMC2698618.

Hemida K, Al Swaff RE, Shabana SS, Said H, Ali-Eldin F. Prediction of Post-operative Mortality in Patients with HCV-related Cirrhosis Undergoing Non-Hepatic Surgeries. J Clin Diagn Res. 2016 Oct;10(10):OC18-OC21. doi: 10.7860/JCDR/2016/22478.8620. Epub 2016 Oct 1. PMID: 27891371; PMCID: PMC5121709.

Downloads

Published

2025-04-02

How to Cite

RISK STRATIFICATION IN CIRRHOTIC PATIENTS UNDERGOING NONHEPATIC SURGERY – LITERATURE REVIEW. (2025). TRAKIA JOURNAL OF SCIENCES, 23(1), 8. https://doi.org/10.15547/tjs.2025.01.010

Similar Articles

1-10 of 13

You may also start an advanced similarity search for this article.